D. discoideum readily consumes approximately 70% of the culturable bacteria that co-occur with it in the wild. What mechanisms underlie this extreme flexibility? Led by graduate student P.M. Shreenidhi in her first first-author publication, the lab’s new paper in PNAS explores this, finding that D. discoideum populations suffer fitness costs when switched from one prey species to another, and often when feeding on multi-species prey communities. Congrats to Shreenidhi and coauthors!